Autosomal Dominant Hyperostosis/Osteosclerosis with High Serum Alkaline Phosphatase Activity

Skeletal alkaline phosphatase activity in serum.

Extremely high maternal alkaline phosphatase serum concentration with syncytiotrophoblastic origin.

An extremely high alkaline phosphatase (AP) concentration (3609 IU/litre) was found in a 20 year old primigravida at 37 week's gestation, prompting an examination of its histological and cellular origin. Immunohistochemistry and western blots using antibodies against AP, Ki-67, phospho-protein kinase B (Akt), phospho-p44/42 mitogen activated protein kinase/extracellular signal regulated kinase ...

Depression of serum alkaline phosphatase activity by human serum albumin.

The daily intravenous administration of 50 gm. of concentrated saltpoor human serum albumin’ produces a rise in serum albumin level and a decline in urinary calcium and phosphorus excretion (1). These latter changes have been interpreted as evidence for an albumin-induced stimulation of osteogenesis (2). The consistent finding of a concomitant depression of serum alkaline phosphatase activity w...

Serum Alkaline Phosphatase

phatase may reflect enzyme contributions from bone, liver, and intestine. We have investigated serum alkaline phosphatases in two siblings with hypophosphatasia. After administration of long-chain triglycerides, the major alkaline phosphatase component of their sera was shown to be of intestinal origin on the basis of inhibition by l-phenylalanine. Starch block electrophoresis suggested that th...

Serum alkaline phosphatase and rickets.

Ch. M. Glasgow A. W. Kay, F.R.C.S., and others ............ 112 Anaesthetic Contamination L. Strnmin, F.F.A.R.C.S ................... 113 Serum Alkaline Phosphatase and Rickets T. C. B. Stamp, M.R.C.P., and Joan M. Round, B.SC . .......................... 113 Hyperactive Children W. C. M. Scott, L.M.S.S.A., D.P.M ........... 113 Calcitonin in Osteogenesis Imperfecta R. Smith, M.D., and others ....